Hyaline and Cystic Degeneration of Uterine Leiomyomas: CT and MR Imaging with Histopathological Sample Analyses.

Leiomyomas are the most common solid benign uterine neoplasms; they are usually asymptomatic and are identified incidentally. Yet, responsive to stimulation by estrogens, leiomyomas may expand, potentially outgrowing their blood supply to undergo hemorrhage, fibrosis, calcification, and atrophy. These pathologic mechanisms commonly lead to leiomyomas degeneration, i.e., red, hyaline, cystic, or myxoid. Magnetic resonance (MR) imaging is the most accurate imaging technique for the characterization of leiomyomas. In cases of degeneration, variable features on T2-weighted and contrast-enhanced images can be found. With no recent radiologic pathologic correlation literature available on this matter, herewith, we provide computed tomography (CT)/MR imaging along with histopathological specimens of two young women who were diagnosed with hyaline or hyaline and cyst degeneration of uterine leiomyomas at our university hospital. We report on the imaging features of uterine leiomyomas using CT and MR imaging and discuss the available literature on imaging signs that may be suggestive of hyaline or cyst degeneration using either of the imaging examination methods.

TOMOGRAPHIC SARCOPENIA PREDICTS ANASTOMOTIC LEAKS AND LONG-TERM SURVIVAL IN GASTRIC CANCER PATIENTS OPERATED WITH CURATIVE INTENT.

BACKGROUND: The preoperative nutritional state has prognostic postoperative value. Tomographic density and area of psoas muscle are validated tools for assessing nutritional status. There are few reports assessing the utility of staging tomography in gastric cancer patients in this field. AIMS: This study aimed to determine the influence of sarcopenia, measured by a preoperative staging computed tomography scan, on postoperative morbimortality and long-term survival in patients operated on for gastric cancer with curative intent. METHODS: This retrospective study was conducted from 2007 to 2013. The definition of radiological sarcopenia was by measurement of cross-sectional area and density of psoas muscle at the L3 (third lumbar vertebra) level in an axial cut of an abdominopelvic computed tomography scan (in the selection without intravascular contrast media). The software used was OsirixX version 10.0.2, with the tool "propagate segmentation", and all muscle seen in the image was manually adjusted. RESULTS: We included 70 patients, 77% men, with a mean cross-sectional in L3 of 16.6 cm2 (standard deviation+6.1) and mean density of psoas muscle in L3 of 36.1 mean muscle density (standard deviation+7.1). Advanced cancers were 86, 28.6% had signet-ring cells, 78.6% required a total gastrectomy, postoperative surgical morbidity and mortality were 22.8 and 2.8%, respectively, and overall 5-year long-term survival was 57.1%. In the multivariate analysis, cross-sectional area failed to predict surgical morbidity (p=0.4) and 5-year long-term survival (p=0.34), while density of psoas muscle was able to predict anastomotic fistulas (p=0.009; OR 0.86; 95%CI 0.76-0.96) and 5-year long-term survival (p=0.04; OR 2.9; 95%CI 1.04-8.15). CONCLUSIONS: Tomographic diagnosis of sarcopenia from density of psoas muscle can predict anastomotic fistulas and long-term survival in gastric cancer patients treated with curative intent.

Tomographic sarcopenia predicts anastomotic leaks and long-term survival in gastric cancer patients operated with curative intent / Sarcopenia tomográfica prevê fístulas de anastomoses e sobrevida a longo prazo em pacientes com câncer gástrico operados com intenção curativa

ABSTRACT BACKGROUND: The preoperative nutritional state has prognostic postoperative value. Tomographic density and area of psoas muscle are validated tools for assessing nutritional status. There are few reports assessing the utility of staging tomography in gastric cancer patients in this field. AIMS: This study aimed to determine the influence of sarcopenia, measured by a preoperative staging computed tomography scan, on postoperative morbimortality and long-term survival in patients operated on for gastric cancer with curative intent. METHODS: This retrospective study was conducted from 2007 to 2013. The definition of radiological sarcopenia was by measurement of cross-sectional area and density of psoas muscle at the L3 (third lumbar vertebra) level in an axial cut of an abdominopelvic computed tomography scan (in the selection without intravascular contrast media). The software used was OsirixX version 10.0.2, with the tool "propagate segmentation", and all muscle seen in the image was manually adjusted. RESULTS: We included 70 patients, 77% men, with a mean cross-sectional in L3 of 16.6 cm2 (standard deviation+6.1) and mean density of psoas muscle in L3 of 36.1 mean muscle density (standard deviation+7.1). Advanced cancers were 86, 28.6% had signet-ring cells, 78.6% required a total gastrectomy, postoperative surgical morbidity and mortality were 22.8 and 2.8%, respectively, and overall 5-year long-term survival was 57.1%. In the multivariate analysis, cross-sectional area failed to predict surgical morbidity (p=0.4) and 5-year long-term survival (p=0.34), while density of psoas muscle was able to predict anastomotic fistulas (p=0.009; OR 0.86; 95%CI 0.76-0.96) and 5-year long-term survival (p=0.04; OR 2.9; 95%CI 1.04-8.15). CONCLUSIONS: Tomographic diagnosis of sarcopenia from density of psoas muscle can predict anastomotic fistulas and long-term survival in gastric cancer patients treated with curative intent.

RESUMO RACIONAL: O estado nutricional pré-operatório tem valor prognóstico pós-operatório. A densidade tomográfica e a área do músculo psoas é uma ferramenta validada para o estado nutricional. Existem poucos estudos avaliando a utilidade da tomografia de estadiamento em pacientes com câncer gástrico neste campo. OBJETIVOS: Determinar a influência da sarcopenia, medida por tomografia computadorizada de estadiamento pré-operatório, na morbimortalidade pós-operatória e sobrevida em longo prazo em pacientes operados de câncer gástrico com intenção curativa. MÉTODOS: Estudo retrospectivo de 2007 a 2013. A definição de sarcopenia radiológica foi pela medida da área (PA) e densidade do músculo psoas (PD) a nível de L3 (Terceira vertebra lombar), em um corte axial de tomografia computadorizada abdominopélvica (na seleção sem meio de contraste intravascular). O Software utilizado foi o OsirixX v 10.0.2, com a ferramenta "propagar segmentação", ajustando manualmente todos os músculos vistos na imagem. RESULTADOS: Foram incluídos 70 pacientes, 77% homens, PA média em L3: 16,6 cm2 (desvio padrão+6,1), PD média em L3: 36,1 mean muscle density (desvio padrão+7,1). Os cânceres avançados foram de 86, 28,6% tinham células em anel de sinete, 78,6% necessitaram de gastrectomia total, a morbidade e mortalidade cirúrgica pós-operatória foi de 22,8 e 2,8%, respectivamente, a sobrevida global de 5 anos a longo prazo (SV5) foi de 57,1%. Na análise multivariada, PA falhou em prever morbidade cirúrgica (p=0,4) e sobrevida global de 5 anos (p=0,34), enquanto PD foi capaz de prever fístulas anastomóticas (p=0,009; OR 0,86; IC95% 0,76-0,96) e SV5 (p=0,04; OR 2,9; IC95% 1,04-8,15). CONCLUSÕES: O diagnóstico tomográfico de sarcopenia por desvio padrão é capaz de predizer fístulas anastomóticas e sobrevida a longo prazo em pacientes com câncer gástrico tratados com intenção curativa.

Neostigmine® Improves Pancreatic Duct Visualization in Magnetic Resonance Cholangiopancreatography and Could Be a Cheap Alternative for Secretin.

BACKGROUND: To determine the effect of intramuscular administration of Neostigmine® on the visualization of the pancreatic duct on magnetic resonance cholangiopancreatography in patients with recurrent acute pancreatitis or abdominal pain. METHODS: We reviewed patients undergoing magnetic resonance cholangiopancreatography followed by a Neostigmine®-enhanced magnetic resonance cholangiopancreatography. Patients with a history of recurrent acute pancreatitis or abdominal pain who had a magnetic resonance cholangiopancreatography where the pancreatic duct was not entirely seen, were selected to undergo a second magnetic resonance cholangiopancreatography 40 minutes after 0.5 mg Neostigmine®. Images were analyzed by 2 radiologists. The diameter of the pancreatic duct was measured in the head, body, and tail of the pancreas on the baseline images and after Neostigmine®. RESULTS: Ten patients were included, with a median age of 33 years (range 15-61). The maximum diameter of the pancreatic duct increased significantly after Neostigmine® administration in all patients, from 1.84 ± 0.98 to 3.41 ± 1.27 mm in the head, 1.34 ± 0.42 mm to 2.5 ± 0.49 mm in the body and 0.72 ± 0.52 mm to 1.78 ± 0.43 mm in the tail (mean ± SD, P < .0001). Neostigmine® helped to provide better detail of the pancreatic duct anatomy in 4 patients. In 2 patients we confirmed pancreas divisum, in another the Santorini duct was not seen on the baseline images but it was clearly visualized after Neostigmine®, and in the fourth patient, Neostigmine® improved visualization of multiple pancreatic duct stenosis. CONCLUSION: Neostigmine®-magnetic resonance cholangiopancreatography significantly increases the diameter of the pancreatic duct, allowing an accurate morphological evaluation. It could be a cheap alternative to secretin, which is expensive and hardly available.

Violencia laboral y su efecto en enfermeras a nivel hospitalario: Una revisión sistemática / Workplace violence and its effect on nurses at the hospital level: A systematic review

OBJETIVO: Identificar efectos de la violencia laboral en enfermeras a nivel intrahospitalario y las estrategias de afrontamiento y prevención de violencia laboral entre enfermeras. MÉTODO: Revisión bibliográfica sistemática cualitativa. Se analizaron artículos publicados en las bases de datos PUBMED, Science Direct, Scielo y LILACS. La estrategia de búsqueda se realizó mediante descriptores en Ciencias de la Salud (DeCS) y el Medical Subject Headings (MeSH) con el operador booleano AND. Se utilizó el diagrama de flujo (PRISMA). La evaluación de la calidad metodológica se realizó mediante las fichas de lectura crítica disponibles en la Plataforma FLC 3.0. RESULTADOS: la violencia y el acoso laboral tienen efectos negativos sobre la salud física y mental, las relaciones interpersonales y en el desempeño laboral de los enfermeros. Entre las estrategias de afrontamiento de la persona que sufre violencia laboral se encuentran el análisis del problema, hablar con alguien de confianza, enfrentar al acosador e involucrar al sistema. Las medidas de prevención a nivel organizacional destacan las capacitaciones, la mejora de normas, establecimiento de sanciones al acosador y la vigilancia de estas situaciones. CONCLUSIÓN: La violencia laboral no solo repercute a la persona afectada, sino también a todo el sistema organizativo en salud. Se enfatiza la importancia de desarrollar medidas y estrategias preventivas de la violencia y acoso laboral.

OBJECTIVE: To identify the effects of workplace violence on nurses at the intrahospital level and the coping strategies and prevention of workplace violence among nurses. METHODOLOGY: Qualitative systematic literature review. Articles published from 2016 to 2021 were analyzed in the PUBMED, Science Direct, Scielo and LILACS databases, of qualitative and quantitative type. The search strategy was performed using descriptors in Health Sciences (DeCS) and Medical Subject Headings (MeSH) with the Boolean operator AND. The flow diagram (PRISMA) was used. The methodological quality of each article was assessed using the critical reading sheets available on the FLC 3.0 platform. Thirteen selected bibliographies were qualitatively analyzed. RESULTS: violence and harassment at work have negative effects on nurses' physical and mental health, interpersonal relationships and work performance. Coping strategies for the person who suffers workplace violence include analyzing the problem, talking to someone they trust, confronting the harasser, and involving the system. Prevention measures at the organizational level include training, improving standards, establishing sanctions for the harasser and monitoring these situations. CONCLUSION: The negative effect of workplace violence not only affects the person affected, but also the entire organizational health system. It is possible to emphasize the importance of establishing preventive measures and strategies against workplace violence and harassment.

Normal amino-terminal pro-brain natriuretic peptide (NT-proBNP) values in amniotic fluid.

INTRODUCTION: Brain natriuretic peptide (BNP) is synthesized by human fetal membranes, both the amnion and chorion. This locally produced BNP inhibits the contraction of the human myometrium, contributing to the maintenance of myometrial quiescence during pregnancy. Reference values for NT-proBNP concentrations in amniotic fluid at different gestational ages have not been completely defined. We aimed to investigate the range of fetal NT-proBNP values in amniotic fluid in normal pregnancy between 17 and 41weeks of gestation. METHODS: Samples of amniotic fluid were obtained from women meeting the following inclusion criteria: gestational age defined by early ultrasound, singleton gestation and not in labor. The exclusion criteria were as follows: multiple gestation, clinically evident chorioamnionitis, laboratory signs of infection in the amniotic fluid sample and fetal conditions that may alter NT Pro-BNP levels (anemia, hydrops, etc.). NT-proBNP concentrations in amniotic fluid were measured using the automated Elecsys® proBNP assay. RESULTS: We analyzed 218 samples of amniotic fluid at various gestational ages. Half of the samples were obtained by amniocentesis (118 samples), and the other half (100 samples) were obtained by direct puncture at the time of cesarean section. We found a significant decline in NT-proBNP concentrations with advancing gestational age. DISCUSSION: Gestational age has to be taken into consideration in the assessment of NT-proBNP values. Our data may be used as reference values in fetal medicine, as a possible predictor of preterm delivery risk using the inferior limit (0.5 multiples of the median (MoM)) of our normal curve.

Does the addition of ezetimibe to statins reduce cardiovascular risk? / ¿Disminuye el riesgo cardiovascular al agregar ezetimibe al tratamiento con estatinas?

Statins are the mainstay of lipid-lowering therapy nowadays, since they reduce cardiovascular risk when used as primary or secondary prevention. However, only one third of the patients reach the goals established in several guidelines, and even if they do, they keep a risk higher than healthy controls. One of the new lipid-lowering agents is ezetimibe. Searching in Epistemonikos database, which is maintained by screening multiple databases, we identified nine systematic reviews comprising 67 trials overall. We combined the evidence using meta-analysis and generated a summary of findings following the GRADE approach. We concluded adding ezetimibe to statins probably results in little or no difference in overall mortality. It might lead to a small reduction in the risk of myocardial infarction and stroke, but the certainty of the evidence is low.

Consultas de urgencia posteriores al terremoto del 27 de febrero 2010, en el hospital de Cauquenes / Post earthquake emergency conbsultatiosn at the Cauquenes hospital, February 27, 2010

Se realizó un estudio descriptivo transversal según frecuencia de consultas en el servicio de urgencia del Hospital San Juan de Dios de Cauquenes, tipo de lesiones, y apoyo utilizado, para caracterizar la morbilidad asociada al sismo ocurrido entre la Quinta y Novena regiones de Chile, el 27 de febrero de 2010. El Universo fue constituido por todos los casos atendidos posteriormente al desastre en dicho servicio, y la información fue recogida a partir de los sistemas de estadísticas continuas de este mismo establecimiento. Fallecieron en la comuna de Cauquenes, 15 personas el día mismo del terremoto, con una tasa de 3,5 por 10.000 habitantes; se registraron 1360 consultas en los primeros 10 días, con predominio de traumatismos superficiales, heridas y fracturas de los miembros. Los resultados obtenidos son de utilidad en el logro de un enfoque más racional para la atención, la prevención y el auxilio ante un desastre en regiones con similares características.

A descriptive, cross sectional study was carried out to characterize the morbidity associated with the earthquake that occurred on February 27, 2010, affecting the Fifth to Ninth administrative regions in Chile. The frequency of consultation, type of injury, and support used in the emergency department of the San Juan de Dios Hospital of Cauquenes were analyzed. The universe consisted in all the cases seen after the disaster at that emergency department, and the information was collected from the current statistics systems at the hospital. In Cauquenes County, there were 15 deaths the day of the earthquake, a mortality rate of 3.5 per 10,000 residents. 1360 consultations were registered in the first 10 days, mainly superficial injuries, wounds and fractures. The obtained results are useful for achieving a more rational approach to care, prevention and aid in a disaster situation with similar characteristics.